No piece of data that does have significance to the Bitcoin consensus can be memorable because it occurs (about) every ten minutes. In order to get something memorable to provide
sanity (let's say, anti-sybil-attack) checking,
it has to be rare, but recurrent. The opportunity is actually already there, but it usually goes by without providing the benefits.
For example, I found
this blog post by Ken Shirriff who describes artifacts that can be found in the blockchain. These artifacts are not intimately tied to their location in the blockchain, so anyone building an alternative blockchain can relatively easily add the artifacts with the same timestamp and at the same height, masking the counterfeit. In order to prevent that, the memorable thing has to be intimately tied to work-intensive results, like the ratio of the hash to the target. Nelson Mandela's image appearing in the blockchain does NOT prove to me it's the blockchain I can see at
blockchain.com right now, but if the smallest block hash in that blockchain, on 12/13/13, after all the zeroes, starts with 3da1 (144 * 65536 times as much work) and is one of the three block hashes from that day that have two occurrences of a double-e (about 256 times more work), then it will. The problem is that I'll probably forget most of those details - but not that Mandela's image went in the blockchain near the end of 2013.